Chronic CNS administration of Agouti-related protein (Agrp) reduces energy expenditure
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice.
Agouti-related protein (Agrp) encodes a hypothalamic neuropeptide that promotes positive energy balance by stimulating food intake and reducing energy expenditure. Agrp expression in the brain is restricted to neurons within the arcuate nucleus of the hypothalamus, and expression levels are elevated as a consequence of food deprivation. We tested a series of bacterial artificial chromosome repo...
متن کاملRapid communication: sequencing of the porcine agouti-related protein (AGRP) gene.
Name of Sequence. Porcine agouti-related protein (AGRP) gene. Genus and Species. Sus scrofa. Origin of Clone. Initially, a 978-bp fragment was amplified from genomic DNA using PCR primers (forward 5′-ATGCTGACCGCAGTGTTGCTGAGC-3′ and reverse 5′-CTAGGTGCGGCTGCAGGGGTTCGT-3′) designed from consensus alignment of human, bovine, and mouse DNA sequences. The PCR product was cloned into the pCR 2.1 vect...
متن کاملEffects of chronic central nervous system administration of agouti-related protein in pair-fed animals.
The melanocortin receptor (MC3-R and MC4-R) antagonist, agouti-related protein (AGRP), is a potent stimulant of food intake. We examined the effect of chronic intracerebroventricular (ICV) AGRP treatment on energy metabolism and pituitary function in ad libitum fed rats and rats administered AGRP and then pair-fed to a saline control group. Chronic ICV AGRP (83-132) administration (1 nmol/day f...
متن کاملDivergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons
OBJECTIVE The sites of insulin action in the central nervous system that regulate glucose metabolism and energy expenditure are incompletely characterized. We have shown that mice with hypothalamic deficiency (L1) of insulin receptors (InsRs) fail to regulate hepatic glucose production (HGP) in response to insulin. RESEARCH DESIGN AND METHODS To distinguish neurons that mediate insulin's effe...
متن کاملIdentification of Distant Agouti-Like Sequences and Re-Evaluation of the Evolutionary History of the Agouti-Related Peptide (AgRP)
The Agouti-like peptides including AgRP, ASIP and the teleost-specific A2 (ASIP2 and AgRP2) peptides have potent and diverse functional roles in feeding, pigmentation and background adaptation mechanisms. There are contradictory theories about the evolution of the Agouti-like peptide family as well the nomenclature. Here we performed comprehensive mining and annotation of vertebrate Agouti-like...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2003
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0802253